USMLE STEP1 BASIC COURSE

Course Content

Books
ENDOCRINE
17 Topics
17 Quizzes
1- thyroid gland (embryo)
Quiz 1
2- pituitary gland (Anatomy)
Quiz 2
3- GH, Prolactin, Thyroid hormone (physiology)
Quiz 3
4- ADH, PTH (physiology)
Quiz 4
5- insulin, glucagon (physiology)
Quiz 5
6- Congenital Adrenal Hyperplasia
Quiz 6
7- Cortisol, SIADA, Diapetes insipidus (physiology – pathology)
Quiz 7
8- pituitary adenoma, Acromegaly (pathology)
Quiz 8
9- Hyperthyroidism, hypothyroidism (pathology)
Quiz 9
10- Hyperthyroidism, graves disease (pathology)
Quiz 10
11- thyroid cancer (pathology)
Quiz 11
12- hyperparathyroidism, hypoparathyroidism (pathology)
Quiz 12
13- Diabetes Mellitus (pathology)
Quiz 13
14- Cushing disease, Adrenal insufficiency (pathology)
Quiz 14
15- Neuroendocrine tumors (pathology)
Quiz 15
16- Diabetes (Pharmacology)
Quiz 16
17- Thyroid (Pharmacology)
Quiz 17
GIT
33 Topics
33 Quizzes
1– Embryology & Anatomy (Part 1)
Quiz 1
2 – Embryology & Anatomy (Part 2)
Quiz 2
3– Retroperitoneal & GI Structures
Quiz 3
4– Vascular Supply & Anorectal Anatomy
Quiz 4
5– Liver & Biliary Structures
Quiz 5
6- Femoral & Inguinal Anatomy
Quiz 6
7- GIT Regulatory Substances & Secretions
Quiz 7
8- Absorption & Adaptations
Quiz 8
9-Oral & Esophageal Pathologies (Part 1)
Quiz 9
10- Oral & Esophageal Pathologies (Part 2) & Gastric Disorders
Quiz 10
11- Peptic Ulcer & Related Disorders
Quiz 11
12- Malabsorption Syndromes
Quiz 12
13- Inflammatory Bowel Diseases
Quiz 13
14- Colitis & Appendicitis
Quiz 14
15- Diverticula of the GI Tract
Quiz 15
16- Congenital & Mechanical Disorders
Quiz 16
17- Functional & Constipation Disorders
Quiz 17
18- Ischemic & Necrotic Disorders
Quiz 18
19- Colonic Polyps & Polyposis Syndromes
Quiz 19
20- Colorectal Cancer & Anal Pathologies
Quiz 20
21- Cirrhosis & Portal Hypertension
Quiz 21
22- Liver Infections & Markers
Quiz 22
23- Chronic Liver Diseases & Tumors (Part 1)
Quiz 23
24-Chronic Liver Diseases & Tumors (Part 2)
Quiz 24
25- Neonatal & Hereditary Hyperbilirubinemias
Quiz 25
26- Metabolic Liver Diseases
Quiz 26
27- Biliary Tract Diseases (Part 1)
Quiz 27
28-Biliary Tract Diseases (Part 2)
Quiz 28
29- Pancreatic Disorders (Part 1)
Quiz 29
30- Pancreatic Disorders (Part 2)
Quiz 30
31- Pharmacology (Part 1)
Quiz 31
32- Pharmacology (Part 2)
Quiz 32
33- pharmacology3.
Quiz 33
Renal
12 Topics
12 Quizzes
1- Embryology.
Quiz 1
2- Renal Anatomy.
Quiz 2
3- Renal Physiology Part1.
Quiz 3
4- Renal Physiology Part2.
Quiz 4
5- Renal Hormones.
Quiz 5
6- Acid – Base Physiology.
Quiz 6
7- Nephritic Syndrome.
Quiz 7
8- Nephrotic Syndrome, Kidney Stones.
Quiz 8
9- Urinary Incontinence, Acute Pylonephritis.
Quiz 9
10- Acute Tubular Necrosis.
Quiz 10
11- Pckd, Renal Cancers.
Quiz 11
12- Renal Pharmacology.
Quiz 12
RESPIRATORY
14 Topics
13 Quizzes
1- Embryology, Cells Of Respiratory System.
Quiz 1
2- Nrds, Anatomy Of The Lung.
Quiz 2
3-Physiology Of Respiratory System 1.
Quiz 3
4- Hemglobin Diseases.
Quiz 4
5-PE
Quiz 5
6-Copd.
Quiz 6
7-Intersticial Lung Diseases.
Quiz 7
8- Pneumoconiosis, Ards.
Quiz 8
9-Pleural Diseases.
Quiz 9
10-Pneumonia.
Quiz 10
11-Lung Cancer.
Quiz 11
12- Uw Additions.
Quiz 12
13-Pharmacology.
Quiz 13
Revision.
CARDIOVASCULAR
62 Topics
59 Quizzes
1-Heart Morphogenesis
Quiz 1
2-Ventricular & Valve Development
Quiz 2
3-Heart Embryology
Quiz 3
4-Fetal Circulation & Vascular Derivatives
Quiz 4
5-Heart Anatomy
Quiz 5
6-Stroke Volume
Quiz 6
7-Preload & Afterload
Quiz 7
8-Cardiac Output & Hemodynamics
Quiz 8
9-Resistance, Pressure, Flow
10-Cardiac & Vascular Function Curves
Quiz 10
11-Exercise Physiology
Quiz 11
12-Pressure-Volume Loops & Cardiac Cycle
13-Heart Sounds & Jugular Venous Pulse
Quiz 13
14-Pressure-Volume Loops & Valvular Disease
Quiz 14
15-Splitting of S2
Quiz 15
16-Auscultation of the Heart
Quiz 16
17-Maneuvers & Cardiovascular Changes
18-Heart Murmurs (Part 1)
Quiz 18
19-Heart Murmurs (Part 2)
Quiz 19
20-Myocardial Action Potential
Quiz 20
21-Pacemaker Action Potential
Quiz 21
22-Electrocardiogram
Quiz 22
23-Natriuretic Peptides & Receptors
Quiz 23
24-Hemodynamics & Autoregulation
Quiz 24
25-Capillary Fluid Exchange
Quiz 25
26-Ventricular Hypertrophy & Aging
Quiz 26
27-Right-to-Left Shunts (Part 1)
Quiz 27
28-Right-to-Left Shunts (Part 2)
Quiz 28
29-Left-to-Right Shunts
Quiz 29
30-Patent Ductus Arteriosus
Quiz 30
31-Congenital Cardiac Defects
Quiz 31
32-Hypertension
Quiz 32
33-Hyperlipidemia & Atherosclerosis
Quiz 33
34-Vascular Disorders (Part 1)
Quiz 34
35-Vascular Disorders (Part 2)
Quiz 35
36-Vascular Syndromes
Quiz 36
37-Ischemic Heart Disease (Part 1)
Quiz 37
38-Ischemic Heart Disease (Part 2)
Quiz 38
39-Evolution of Myocardial Infarction
Quiz 39
40-Diagnosis of Myocardial Infarction
Quiz 40
41-Narrow Complex Tachyarrhythmias
Quiz 41
42-Supraventricular Tachycardias
Quiz 42
43-Wide Complex Tachyarrhythmias
Quiz 43
44-Conduction Blocks & Premature Beats
Quiz 44
45-Myocardial Infarction Complications
Quiz 45
46-Acute Coronary Syndrome & Cardiomyopathies (Part 1)
Quiz 46
47-Cardiomyopathies (Part 2)
Quiz 47
48-Heart Failure (Part 1)
Quiz 48
49-Heart Failure (Part 2)
Quiz 49
50-High-Output Heart Failure & Shock
Quiz 50
51-Cardiac Tamponade
Quiz 51
52-Syncope & Endocarditis
Quiz 52
53-Pericardial & Rheumatic Disorders
Quiz 53
54-Myocarditis & Miscellaneous Disorders
Quiz 54
55-Cardiovascular Agents (Part 1)
Quiz 55
56-Cardiovascular Agents (Part 2)
Quiz 56
57-Hypertension Treatment
Quiz 57
58-Lipid-Lowering Agents
Quiz 58
59-Digoxin
Quiz 59
60-Antiarrhythmics (Class I – Sodium Channel Blockers)
Quiz 60
61-Antiarrhythmics (Class II – β-blockers)
Quiz 61
62-Antiarrhythmics (Class III & IV)
Quiz 62
Haematology
43 Topics
39 Quizzes
1- Fetal erythropoiesis
Quiz 1
2-Blood groups
3-hemolytic disease of newborn
Quiz 3
4-Hematopoiesis
Quiz 4
5-Blood Cells
6-Blood Cells 2
Quiz 6
7-Blood Cells 3
8-Hemoglobin electrophoresis
Quiz 8
9-Platelet plug formation
Quiz 9
10-Coagulation pathways
Quiz 10
11-Vitamin K–dependent factors
Quiz 11
12-Anemias (Microcytic anemia)
Quiz 12
13-thalassemia
Quiz 13
14-Lead poisoning
Quiz 14
15-Macrocytic anemia
Quiz 15
16-Normocytic anemias
Quiz 16
17-Normocytic anemias 2 (Aplastic anemia)
Quiz 17
18-Normocytic anemias 3
Quiz 18
19-Normocytic anemias 4
Quiz 19
20-Sickle cell anemia
Quiz 20
21-Autoimmune hemolytic anemia
Quiz 21
22-Heme synthesis pathway disorders
Quiz 22
23-Coagulation disorders1
24-Coagulation disorders2
Quiz 24
25-Coagulation disorders3
Quiz 25
26-Platelet disorders overview
Quiz 26
27-Thrombotic microangiopathies
Quiz 27
28-Mixed platelet and coagulation disorders
Quiz 28
29-Hereditary thrombophilias
Quiz 29
30-Leukemia and lymphoma
Quiz 30
31-Non-Hodgkin lymphoma
Quiz 31
32-Plasma cell dyscrasias
Quiz 32
33-Myelodysplastic syndrome
Quiz 33
34-Leukemias
Quiz 34
35-Myeloproliferative neoplasms
Quiz 35
36-Notes
Quiz 36
37-Heparin
Quiz 37
38-Warfarin
Quiz 38
39-Other anticoagulants and antiplatelet
Quiz 39
40-Cancer therapy 1
Quiz 40
41-Cancer therapy 2
Quiz 41
42-Cancer therapy 3
Quiz 42
43-Cancer therapy 4
Quiz 43
Neurology
62 Topics
61 Quizzes
1- Neural development
Quiz 1
2-nervous system origins and defects
Quiz 2
3- CNS malformations
Quiz 3
4-Syringomyelia
Quiz 4
5- Cells of the nervous system
Quiz 5
6-Action potential and receptors
Quiz 6
7- Peripheral nerve and nerve injury
Quiz 7
8-Meninges and BBB
Quiz 8
9-Sleep physiology
Quiz 9
10-Hypothalamus and Thalamus
Quiz 10
11-Limbic system
Quiz 11
12- Cerebellum
Quiz 12
13-Basal ganglia
Quiz 13
14-Cerebral cortex
Quiz 14
15-Cerebral arteries and Circle of Willis
Quiz 15
16-Ventricular system
Quiz 16
17-Brainstem
18-Cranial nerves 1
Quiz 18
19-Cranial nerves 2
Quiz 19
20-Spinal cord levels and tracts
Quiz 20
21-Reflexes and Landmark dermatomes
Quiz 21
22-Common brain lesions
Quiz 22
23-Ischemic brain disease
Quiz 23
24-Effects of strokes 1
Quiz 24
25-Effects of strokes 2
Quiz 25
26-Neonatal intracranial and extracranial hemorrhages
Quiz 26
27- Intracranial hemorrhage
Quiz 27
28- Diffuse axonal injury and Aphasia
Quiz 28
29-Aneurysms
Quiz 29
30-Seizures
Quiz 30
31- Headaches
Quiz 31
32-Dyskinesias and Restless legs syndrome
Quiz 32
33-Neurodegenerative movement disorders
Quiz 33
34-Dementia
Quiz 34
35-Hydrocephalus
Quiz 35
36-Multiple sclerosis
Quiz 36
37-Other demyelinating disorders
Quiz 37
38- Neurocutaneous disorders
Quiz 38
39-Adult primary brain tumors
Quiz 39
40-Childhood primary brain tumors
Quiz 40
41- Herniation syndromes
Quiz 41
42-Spinal cord lesions 1
Quiz 42
43-Spinal cord lesions 2
Quiz 43
44-Common cranial nerve lesions
Quiz 44
45- Auditory anatomy and physiology
Quiz 45
46-Common causes of hearing loss
Quiz 46
47-Normal eye anatomy and Conjunctivitis
Quiz 47
48-Refractive errors and Lens disorders
Quiz 48
49- Aqueous humor pathway and Glaucoma
Quiz 49
50-Retinal disorders 1
Quiz 50
51-Retinal disorders 2
Quiz 51
52- Pupillary control
Quiz 52
53- Ocular motility and motility disorders
Quiz 53
54- Visual field defects
Quiz 54
55- Internuclear ophthalmoplegia and Eyelid disorders
Quiz 55
56-Anticonvulsants
Quiz 56
57-Insomnia therapy
Quiz 57
58-Parkinson and other Neurodegenerative diseases therapy
Quiz 58
59-anesthetics
Quiz 59
60-Neuromuscular blocking drugs and Skeletal muscle relaxants
Quiz 60
61- Opioid analgesics
Quiz 61
62- Glaucoma therapy
Quiz 62
psychiatry
25 Topics
25 Quizzes
1 – Learning & Psychodynamics
Quiz 1
2 – Ego Defenses
Quiz 2
3 – Grief & Development
Quiz 3
4 – Child Abuse
Quiz 4
5 – Childhood & Early-Onset Disorders
Quiz 5
6 – Neurodevelopmental & Behavioral Disorders
Quiz 6
7 – Orientation & Dissociation
Quiz 7
8 – Psychosis & Schizophrenia Spectrum
Quiz 8
9 – Bipolar Spectrum
Quiz 9
10 – Depressive Disorders
Quiz 10
11 – Peripartum Mood Disturbances
Quiz 11
12 – Anxiety Disorders
Quiz 12
13 – OCD & Trauma Disorders
Quiz 13
14 – Personality Disorders
Quiz 14
15 – Somatic & Factitious Disorders
Quiz 15
16 – Eating Disorders
Quiz 16
17 – Gender & Sleep Disorders
Quiz 17
18 – Substance Use & Cognitive Disorders
Quiz 18
19 – Psychiatric Emergencies
Quiz 19
20 – Psychoactive Drug Intoxication & Withdrawal (Part 1)
Quiz 20
21 – Psychoactive Drug Intoxication & Withdrawal (Part 2)
Quiz 21
22 – Psychiatry Pharmacology (Part 1)
Quiz 22
23 – Psychiatry Pharmacology (Part 2)
Quiz 23
24 – Antidepressants (Part 1)
Quiz 24
25 – Antidepressants (Part 2) & Addiction Therapy
Quiz 25
Biochemistry
28 Topics
27 Quizzes
1- Dna Structure.
Quiz 1
2- Pyrimidens, Purines Pathways.
Quiz 2
3- Dna Replication.
Quiz 3
4- Dna Mutations.
Quiz4
5- Transcription.
Quiz 5
6- Protein Synthesis.
Quiz 6
7- Cell Cycle.
Quiz 7
8- Cytoskeleton.
Quiz 8
9- Collagen.
Quiz 9
10- Laboratory Techniques.
Quiz 10
11- Genetic Terms.
Quiz 11
12- Mode Of Transmissions.
13- Hardy Weinberg NEW.
Quiz 13
14- Cystic Fibrosis.
Quiz 14
15- Genetic Diseases.
Quiz 15
16- Vitamins1.
Quiz 16
17- Vitamins2.
Quiz 17
18- Glycolysis.
Quiz 18
19- Krebs Cycle.
Quiz 19
20- Etc.
Quiz 20
21- Fructose, Galactose Disorders.
Quiz 21
22- Urea Cycle.
Quiz 22
23- Metabolic Disorders.
Quiz 23
24- Glycogen Diseases.
QUIZ 24
25- Lysosomal Storage Diseases
QUIZ 25
26- Fatty Acid Metabolism.
Quiz 26
27- Libid Transport.
Quiz 27
28- Uworld Additions.
Quiz 28
Reproductive
34 Topics
34 Quizzes
1– Early Embryonic Development
Quiz 1
2– Teratology
Quiz 2
3 – Placenta & Fetal Membranes
Quiz 3
4– Urachus & Pharyngeal Apparatus
QUIZ 4
5 – Orofacial & Genital Embryology
Quiz 5
6– Genital Anomalies
Quiz 6
7– Reproductive Anatomy & Drainage
Quiz 7
8 – Pelvic & GU Pathology
Quiz 8
9– Male Sexual Response
Quiz 9
10 – Gametogenesis & Hormones
Quiz 10
11– Ovulation & Pregnancy Basics
Quiz 11
12– Physiological Changes in Pregnancy
Quiz 12
13 – Neonatal Assessment
Quiz 13
14 – Puberty & Screening
Quiz 14
15– Sex Development Disorders
Quiz 15
16– Specific Disorders of Sex Development
Quiz 16
17 – Placental Disorders
Quiz 17
18– Pregnancy Complications
Quiz 18
19– Gestational Trophoblastic Disease
Quiz 19
20 – Hypertension in Pregnancy
Quiz 20
21 – Gynecologic Pathology
Quiz 21
22 – Vaginal & Ovarian Disorders
Quiz 22
23– Ovarian & Cervical Disorders
Quiz 23
24 – Ovarian Tumors
Quiz 24
25 – Endometrial & Uterine Pathology
Quiz 25
26– Breast Pathology (Benign)
Quiz 26
27 – Breast Cancer
Quiz 27
28– Penile Pathology
Quiz 28
29– Scrotal Disorders
QUIZ 29
30– Testicular Tumors
Quiz 30
31 – Male Reproductive Pathology
Quiz 31
32– Hormonal Control & Therapy
Quiz 32
33 – Hormonal Modulators
Quiz 33
34 – Contraception & Androgen Therapy
Quiz 34
Muscloskeletal
39 Topics
38 Quizzes
1- Upper Extremity Nerves (Part 1)
Quiz 1
2- Upper Extremity Nerves (Part 2) & Rotator Cuff
Quiz 2
3- Brachial Plexus Lesions
Quiz 3
4- Wrist & Hand Anatomy
Quiz 4
5- Knee & Hip Examination
Quiz 5
6- Lower Extremity Nerves (Part 1)
Quiz 6
7- Lower Extremity Nerves (Part 2)
Quiz 7
8- Clinical Tests & Neuropathies
Quiz 8
9- Motor Neuron Physiology
Quiz 9
10- Muscle Fiber Types & Smooth Muscle
Quiz 10
11- Muscle Proprioceptors & Bone Biology
Quiz 11
12- Upper Limb Injuries
Quiz 12
13- Common Knee & Hand Conditions
Quiz 13
14- Common Musculoskeletal Disorders (Part 1)
Quiz 14
15- Common Musculoskeletal Disorders (Part 2) & Pediatric Conditions
Quiz 15
16- Pediatric Fractures & Bone Disorders (Part 1)
Quiz 16
17- Bone Disorders (Part 2)
QUIZ 17
18- Primary Bone Tumors
Quiz 18
19- Osteoarthritis vs Rheumatoid Arthritis
Quiz 19
20- Crystal-Induced Arthritis
Quiz 20
21- Juvenile & Septic Arthritis
Quiz 21
22- Osteomyelitis & Seronegative Spondyloarthritis
Quiz 22
23- Autoimmune Connective Tissue Diseases
Quiz 23
24- Muscle & Soft Tissue Disorders
Quiz 24
25- Vasculitides (Part 1)
Quiz 25
26- Vasculitides (Part 2)
Quiz 26
27- Neuromuscular Junction & Connective Tissue Disorders
Quiz 27
28
29- Dermatology Basics
Quiz 29
30- Pigmented Skin Disorders
Quiz 30
31- Common Dermatologic Conditions (Part 1)
Quiz 31
32- Common Dermatologic Conditions (Part 2)
Quiz 32
33- Skin Infections (Part 1)
Quiz 33
34- Skin Infections (Part 2) & Blistering Disorders
Quiz 34
35- Blistering Disorders & Ulcers
Quiz 35
36- Miscellaneous Dermatologic Conditions
Quiz 36
37- Skin Cancer & Miscellaneous Conditions
Quiz 37
38- Pharmacology (Part 1)
Quiz 38
39- Pharmacology (Part 2)
Quiz 39
IMMUNOLOGY
12 Topics
4 Quizzes
1- Immune System Organs.
1
2- Innate, Adaptive Immunity.
2
3- B, T Cells Activations.
3
4-Immunoglobulins.
4
5-Complements, In.
6- Vaccination.
7-Hypersensitivity Reactions.
8-Immunedificencies.
9-Transplant Rejection.
10- Pharmacology.
New.
Revision.
Microbiology
55 Topics
1-Clinical Bacteriology
2-Staphylococci
3-Streptococci (Part 1)
4-Streptococci (Part 2)
5-Bacillus & Clostridioides
6-Clostridia
7-Corynebacterium & Related
8-Mycobacteria
9-Gram-negative Basics
10-Respiratory Gram-negatives
11-Pseudomonas aeruginosa
12-Enteric Pathogens (Part 1)
13-Enteric Pathogens (Part 2)
14-GI Pathogens
15-Spirochetes
16-Syphilis
17-Chlamydiae & Zoonoses
18-Rickettsial & Vector-borne Illnesses
19-Mycology (Systemic)
20-Opportunistic Fungi
21-Parasitology (GI & CNS Protozoa)
22-Parasitology (Hematologic & Others)
23-Nematodes (Roundworms)
24-Cestodes, Trematodes & Ectoparasites
25-Basic Bacteriology
26-Special Culture Requirements
27-Bacterial Properties
28-Bacterial Genetics
29-Bacteria with Exotoxins & Endotoxin
30-Virology Basics
31-DNA Viruses
32-Herpesviruses
33-RNA Viruses (Part 1)
34-RNA Viruses (Part 2)
35-Arboviruses & Rabies
36-Emerging Viruses
37-Hepatitis Viruses
38-Hepatitis Complications
39-HIV
40-HIV-related Diseases & Prions
41-Normal Microbiota & Common Infections
42-CNS & Bone Infections
43-UTIs & Vaginal Infections
44-STIs & TORCH
45-PID & Special Groups
46-Antimicrobial Therapy (Overview)
47-Penicillins
48-Other Cell Wall Agents
49-Protein Synthesis Inhibitors (Part 1)
50-Folate & DNA Agents
51-Antituberculous & Antimycobacterial Therapy
52-Antifungal & Antiparasitic Therapy
53-Antiviral Agents (Part 1)
54-HIV Therapy
55-Hepatitis C Therapy & Special Considerations
General Pathology
11 Topics
1– Cellular Adaptations
2– Cell Injury
3– Necrosis & Ischemia
4 – Free Radical Injury & Deposits
5– Inflammation Basics
6– Acute & Chronic Inflammation
7 – Granulomas & Neoplasia
8– Cancer Biology
9– Oncogenes & Tumor Suppressors
10– Carcinogenesis & Markers
11– Paraneoplastic Syndromes & Aging
General pharmacology
15 Topics
1-Pharmacokinetics & Pharmacodynamics
2-Receptor Binding & PK Basics
3-Clearance & Dosage
4-Drug Metabolism & Elimination
5-Autonomic Receptors
6-Pain & Micturition
7-Adrenergic Receptors & ANS
8-Autonomic Drugs (Part 1)
9-Autonomic Drugs (Part 2)
10-Sympathomimetics (Part 1)
11-Sympathomimetics (Part 2) & Sympatholytics
12-β-blockers
13-Phosphodiesterase Inhibitors
14-Ingested Seafood Toxins
15-Toxicology & Miscellaneous
Ethics
13 Topics
1- Autonomy, Beneficience, Descision making capacity
2- informed consent, consent for minors
3- Advance directives
4- Communication skills, delivering bad news!
5- Culture, motivational interviewing, trauma informed
6-  Ethical scenarios 1
7- Ethical scenarios 2
8- Patients with disabilitis, interpreters
9- Ethical scenarios 3
10- Ethical scenarios 4
11- Ethical scenarios 5
12- medical insurance, medicare, medicaid
13- medical errors, palliative care
Statistics
11 Topics
1- Observational Studies
2- Relative risk, odds ratio, …
3- Clinical trials
4- Sensitivity, Specificity, PPV, NPV
5- likelihood ratio, Demographic transitions, others
6- Precision, Accuracy, Prevelance, Incidence
7- Bias, Study errors
8- Confounding, Effect modification, Statistical distribution
9-  Null hypophysis, P value, testing errors
10- Confidence interval, T test, ANOVA, other statistical tests
11- UWORLD Additions, new question ideas
USMLE With HOSSAM